Abnormalities in Glucose Blood Level during Antipsychotic Treatment in Schizophrenia Patients

Background: Schizophrenia is one of the mental disorder with many problematic issues, in both psychologically and socially. This disease requires provision long-term antipsychotic therapy, hence could rise other potential health problems. Antipsychotic treatment can cause serious glucometabolic side-effects, including type 2 diabetes hyperglycemic emergency. Recent attention has also been focused on antipsychotic-induced emergencies experienced by new users typical atypical antipsychotic. Patients treated APDs have ~10 times higher risk developing hyperglycaemic emergencies. In our pre-eliminary study, hyperglycemia condition patients occurs four seven who received antipsychotics. often overlooked not routinely evaluated. Moreover, it develop into increase morbidity mortality schizophrenia patients. this we would like to determine acute effects metabolic (hyperglycemia) (Risperidone Haloperidol) Measurement blood sugar levels was performed groups haloperidol (N = 15) risperidone 15). Plasma samples were taken at beginning treatment, week IV, VIII. The measurement glucose after meal early morning before breakfast (fasting level 8 hours).
 Results: meals significantly Risperidone group compared Haloperidol (p <0.001) IV VIII weeks. Meanwhile, fasting weeks ( p <0.001).
 Conclusions: Both antipsychotics an levels. Treatment increased haloperidol. needed monitor effect antipsychotic, especially Risperidone. It necessary dietary regulation physical activities prevent undesired side effects.